· Developed hypotheses to test mechanisms of T-cell depletion following the use of Thymoglobulin in Type 1 Diabetes; ran functional tests on human T-cells, including cell-trace-violet proliferation and T-reg suppression assays 

· Optimized 11-color flow cytometry protocols for human immunophenotyping of peripheral blood mononuclear cells from a multi-site clinical trial to understand how individuals respond to Thymoglobulin+Neulasta treatment

· Leveraged data from pre-clinical model experiments and comprehensive literature search to develop a streamlined protocol for processing patient samples adhering to ICH/GCP; the protocol is now implemented in 4 labs and has been used on over 700 samples from clinical trials

· Founded partnership with pediatric endocrinologists, biostatisticians, and pathologists to define the role of neutrophils in type 1 diabetes and determine its role as a biomarker for disease

· Managed and trained a team of research assistants, including 1 resident physician fellow, 4 undergraduates; effort resulted in the completion of experiments that helped secure grant from Juvenile Diabetes Research Foundation

Lin A., Hull M., Flynn R., Bruggeman B., Schatz D., Brusko T., Atkinson M., Haller M., Mathews C., Neutrophils and their impacts in Type 1 Diabetes. In Preparation

Lin A., Hull M., Lambert M., Haller M., Mathews C., Thymoglobulin and its Mechanism of Action on the CD8 T-cell. In Preparation. 

Lin A., Bruggeman B., Mathews C., Gurka M., Haller M. Anti-Thymocyte Globulin and Neulasta Immunotherapy for Type 1 Diabetes: 5 –Year Outcomes and Changes In Preparation.

Liu C., Whitener RL., Lin A., Xu Y, Chen J., Savinov A., Leiding JW., Wallet MA., Mathews CE. Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T-Cell Activation via Cross-Presentation in Type 1 Diabetes. Front Immunol. 2019 May.

Lin A., Bray J., Fettis M., Fernandez-Bueno G., Bokor J., Koroly MK. Development and Outcomes from a Translational Science Curriculum for Pre- Collegiate Students. Journal of Stem Outreach. 2019 Jan 24.

Mathews CE., Xue S., Posgai A., Lightfoot YL., Li X., Lin A,Wasserfall C., Haller MJ., Schatz D., Atkinson MA. Acute Versus Progressive Onset of Diabetes in NOD Mice - Potential Implications for Therapeutic Interventions in Type 1 Diabetes. Diabetes. 2015 Jul 27. 

Vincentz, J., Firulli B., Lin A., Spicer D., Howard M., Firulli, T. Twist1 controls a cell specification switch governing cell fate decisions within the cardiac neural crest. PLOS Genetics. 21, March 2013.